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Effects of Lead Poisoning of Rats During Pregnancy on the Reproductive System and Fertility of their Offspring

Commissariat à l'Energie Atomique, Direction des Sciences du Vivant, Département de Pathologie et de Toxicologie Expérimentales, Laboratoire de Radiotoxicologie, BP 12, F91680 Bruyères le Châtel

Annick Thoreux-Manlay

Commissariat à l'Energie Atomique, Direction des Sciences du Vivant, Département de Pathologie et de Toxicologie Expérimentales, Laboratoire de Radiotoxicologie, BP 12, F91680 Bruyères le Châtel

Ghislaine Pinon-Lataillade

Commissariat à l'Energie Atomique, Direction des Sciences du Vivant, Département de Pathologie et de Toxicologie Expérimentales, Laboratoire de Radiotoxicologie, BP 12, F91680 Bruyères le Châtel

Georges Monchaux

Direction des Sciences du Vivant, Département de Pathologie et de Toxicologie Expérimentales, C.E.N. BP 6 F92265 Fontenay aux Roses Cedex

Roland Masse

Direction des Sciences du Vivant, Département de Pathologie et de Toxicologie Expérimentales, C.E.N. BP 6 F92265 Fontenay aux Roses Cedex

Jean-Claude Soufir

Biologie cellulaire, CHU Bicêntre - Université Paris XI, 78 rue du Général Leclerc F94270 Kremlin-Bicêtre, France

1 The effects of lead poisoning during pregnancy were tested on female Sprague-Dawley rats that inhaled 5 mg m^-3 lead oxide for 13 days during gestation. At the end of gestation, the respective blood lead levels of dams and fetuses were 71.1 and 83.2 µg 100 ml^-1, indicating lead poisoning.

2 In the 90 day-old male offspring of the exposed dams, testis weight and histology, and epididymal weight and sperm reserve, were all similar to those of control males. Spermatozoa mobility and morphology were normal.

3 Also similar to control values were the pituitary weight in these male offspring, their plasma FSH, LH and testosterone levels, and the weight of their ventral prostate and seminal vesicles, the targets of the sexual hormones.

4 When male and female offspring of exposed dams were mated, their fertility was normal, with no increase in prenatal death or malformations, and no changes in the size or sex ratio of litters.

5 These results indicate that, under our experimental conditions, lead oxide inhalation by rats during pregnancy did not perturb reproductive function in their male offspring.

Human & Experimental Toxicology, Vol. 13, No. 4, 241-246 (1994)
DOI: 10.1177/096032719401300403


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				G. Pinon-Lataillade, A. Thoreux-Manlay, H. Coffigny, R. Masse, and J-C. Soufir Reproductive toxicity of chronic lead exposure in male and female mice Human and Experimental Toxicology, November 1, 1995; 14(11): 872 - 878. [Abstract] [PDF]