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Phenyl Valerate and Choline Ester Hydrolases in the Platelets of Human, Hen, Rat and Mouse

Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Gwalior-474002, India

1 The levels of phenyl valerate and choline ester hydrolases in the platelets of human and certain laboratory animals have been determined for comparison.

2 The activities of total phenyl valerate hydrolase (PVase), paraoxon insensitive phenyl valerate hydrolase (PI-PVase), paraoxon and mipafox resistant esterase (PMRE) and propionylcholinesterase (PChE) were maximal in hen followed by mouse, rat and human.

3 Neurotoxicesterase (NTE) and acetylcholinesterase (AChE) activities were concentrated in the platelets of hens followed by humans, rats and mice in order.

4 Maximum concentration of butyrylcholinesterase (BChE) was found in the platelets of hens followed by mice, humans and rats.

5 It is concluded that the normal levels of enzyme activities in the platelets of humans and various species of animals may help to evaluate the exposure risk to neurotoxic organophosphorous compounds.

Human & Experimental Toxicology, Vol. 13, No. 3, 157-159 (1994)
DOI: 10.1177/096032719401300303


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