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Persistence of Sodium Monofluoroacetate in Livestock Animals and Risk to Humans

Manaaki Whenua-Landcare Research New Zealand Ltd, P.O. Box 31-011, Christchurch, New Zealand

R. Gooneratnel

Animal and Veterinary Sciences Department, Lincoln University, Lincoln, New Zealand

H. Fitzgerald

Manaaki Whenua-Landcare Research New Zealand Ltd, P.O. Box 31-011, Christchurch, New Zealand

G. Wright

Manaaki Whenua-Landcare Research New Zealand Ltd, P.O. Box 31-011, Christchurch, New Zealand

C. Frampton

Manaaki Whenua-Landcare Research New Zealand Ltd, P.O. Box 31-011, Christchurch, New Zealand

1 Sodium monofluoroacetate (1080), a vertebrate pesticide widely used in New Zealand, was administered orally to sheep and goats at a dose level of 0.1 mg kg^-1 body weight to assess risk to humans of secondary poisoning from meat. Blood, muscle, liver, and kidney were analysed for 1080 residues.

2 The plasma elimination half-life was 10.8 h in sheep and 5.4 h in goats. Concentrations of 1080 in muscle (0.042 ?g g^-1), kidney (0.057 ?g g^-1), and liver (0.021 ?g g^-1) were substantially lower than those in plasma (0.098 ?g m^-1) at 2.5 h after dosing.

3 Only traces of 1080 (<0.002 to 0.008 ?g g^-1) were found in sheep tissues after 96 hours.

4 Livestock are normally excluded from areas where 1080 is being used for pest control, reducing the risk of secondary poisoning. Even with accidental exposure to a sublethal dose 1080 would not persist in tissues for more than a few days because it is cleared rapidly from the body. Therefore the occurrence of 1080 in meat intended for human consumption is highly unlikely.

Human & Experimental Toxicology, Vol. 13, No. 2, 119-122 (1994)
DOI: 10.1177/096032719401300210


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