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Vitamin C in CC14 Hepatotoxicity-A Preliminary Report

Department of Biochemistry, College of Health Sciences, Ogun State University, Ago-Iwoye, Nigeria

O. Adesanya

Department of Biochemistry, College of Health Sciences, Ogun State University, Ago-Iwoye, Nigeria

O.R. Ajuwon

Department of Biochemistry, College of Health Sciences, Ogun State University, Ago-Iwoye, Nigeria

1 The hepatotoxic effect of CC14 was studied in the rat by using 3 well established liver function tests (plasma glucose, bilirubin and proteins) as indices of hepatic integrity.

2 The protective effect of vitamin C against this hepatotoxicity was also investigated.

3 CC 14 (8 ml kg ^-1 body weight) caused a decrease in the levels of plasma conjugated bilirubin, glucose and protein.

4 Vitamin C (2 g kg ^-1 body weight) prevented liver damage induced by CC14. The possible mechanisms of protection are highlighted.

Human & Experimental Toxicology, Vol. 13, No. 2, 107-109 (1994)
DOI: 10.1177/096032719401300208


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