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Elimination Studies of Antipyrine and its Metabolites in Healthy Saudi Arabians

Department of Medicine, King Faisal Specialist Hospital and Research Centre, PO Box 3354, Riyadh 11211, Saudi Arabia

Adnan El-Yazigi

Department of Biological and Medical Research, King Faisal Specialist Hospital and Research Centre, PO Box 3354, Riyadh 11211, Saudi Arabia

Jens O. Sieck

Department of Medicine, King Faisal Specialist Hospital and Research Centre, PO Box 3354, Riyadh 11211, Saudi Arabia

Martin Døssing

Medical Department P, Bispebjerg Hospital, 23-Bispebjerg Bakke, 2400 Copenhagen NV, Denmark

Jalal Saour

Department of Medicine, King Faisal Specialist Hospital and Research Centre, PO Box 3354, Riyadh 11211, Saudi Arabia

Dale A. Raines

Department of Biological and Medical Research, King Faisal Specialist Hospital and Research Centre, PO Box 3354, Riyadh 11211, Saudi Arabia

Peter Ernst

Department of Oncology, King Faisal Specialist Hospital and Research Centre, PO Box 3354, Riyadh 11211, Saudi Arabia

1 We measured the antipyrine clearance in 18 healthy Saudi subjects and determined the urinary excretion of three of its metabolites: 4-hydroxyantipyrine (4-OH AP), norantipyrine (NOR AP) and 3 hydroxymethylantipyrine (3-OHM AP) in 21 subjects.

2 The mean ± SD of the antipyrine clearance was 2.4 ± 1.1 h^-1 (range 1.0-5.5 l h^-1) and the corresponding value per kg body weight was 0.6 ± 0.2 ml min^-1 kg^-1. Urinary excretion of antipyrine (AP), 4-OH AP, NOR AP and 3-OHM AP expressed as a percentage of the oral dose of antipyrine given was 2.8 ± 2.2, 14.5 ± 6.9, 12.3 ± 5.6 and 7.6 ± 3.2 respectively.

3 Compared to Africans, Saudis preferentially metabolize AP to NOR AP and compared to Caucasians to 3-OHM AP, rather than to 4-OH AP. These discrepancies may reflect age differences between the study populations rather than genetic or ethnic variations.

Human & Experimental Toxicology, Vol. 13, No. 10, 658-662 (1994)
DOI: 10.1177/096032719401301002


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