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Efficacy of 4-Methylpyrazole in Ethylene Glycol Poisoning: Clinical and Toxicokinetic Aspects

Centre Anti-Poisons - R�animation M�dicale, CHU, 49033 Angers, Cedex 01 France

A. Turcant

Laboratoire de Pharmacologie et Toxicologie, CHU, 49033 Angers Cedex 01 France

G. Bouachour

Centre Anti-Poisons - R�animation M�dicale, CHU, 49033 Angers, Cedex 01 France

P. Houze

Laboratoire de Biochimie et Pharmacologie, Centre Hospitalier, 78150 Le Chesnay, France

P. Alquier

Centre Anti-Poisons - R�animation M�dicale, CHU, 49033 Angers, Cedex 01 France

P. Allain

Laboratoire de Pharmacologie et Toxicologie, CHU, 49033 Angers Cedex 01 France

Potentially fatal ethylene glycol intoxication in an adult with normal renal function was treated with 4-methylpyrazole administered three hours after the incident occurred. The plasma ethylene glycol concentration was 3.5 g 1^-1 on admission. The metabolic acidosis present on admission resolved within four hours, and the subsequent clinical course was uneventful. The apparent plasma half-life of ethylene glycol was 16 h and the mean renal and plasma clearances of ethylene glycol were 24 and 25 ml min^-1, respectively. These results support the hypothesis that complete blockade of hepatic metabolism of ethylene glycol is achieved by 4-methylpyrazole. The only side-effect observed as a result of treatment was a transient slight increase in serum transaminase activity.

Human & Experimental Toxicology, Vol. 13, No. 1, 61-64 (1994)
DOI: 10.1177/096032719401300109


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