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In Vitro Studies on the Metabolism of Antipyrine in the Pig and Rat: with Special Refierence to Veterinary Medicine Licensing

Department of Pharmacology, Veterinary Faculty, University of Extremadura, Caceres 10071, Spain

Ian C. Shaw

Centre for Toxicology, University of Central Lancashire, Preston PR1 2HE, UK

Preparation of product licence applications for veterinary medicines requires metabolic studies in the target species. This experimental procedure uses animals and is costly. In the present report of preliminary studies it is demonstrated that pig liver homogenates prepared from abattoir material and homogenates of rat liver show the interspecies metabolic differences that would be expected in vivo. The results therefore support the use of abattoir-derived liver homogenates in preliminary studies to investigate target species metabolism in veterinary drug development.

Human & Experimental Toxicology, Vol. 12, No. 6, 537-539 (1993)
DOI: 10.1177/096032719301200613


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