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Human & Experimental Toxicology
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Urinary Protein Excretion and the Diagnosis of Graft Rejection or Renal Dysfunction in Renal Transplant Patients

Mojgan Hossein-Nia

The Analytical Unit, Department of Cardiological Sciences, St George's Hospital Medical School, London SW17 0RE

George J. Mellotte

South West Thames Renal Unit, St Helier Hospital, Carshalton, Surrey SM5 1AA, UK

Peta Foxall

South West Thames Renal Unit, St Helier Hospital, Carshalton, Surrey SM5 1AA, UK

Mike R. Bending

South West Thames Renal Unit, St Helier Hospital, Carshalton, Surrey SM5 1AA, UK

David W. Holt

The Analytical Unit, Department of Cardiological Sciences, St George's Hospital Medical School, London SW17 0RE

Urinary proteins have been found to be a sensitive marker of renal damage caused by nephrotoxic agents. An electrophoretic method was used to investigate the potential value of the pattern of urinary protein excretion in 14 cyclosporin-treated renal transplant patients, to differentiate between graft rejection episodes and other causes of renal dysfunction. Urinary protein excretion consistent with renal damage was observed in all of the patients studied, with no marked differences between those with signs of graft rejection, those with renal dysfunction, or those with stable renal function.

Human & Experimental Toxicology, Vol. 12, No. 5, 407-409 (1993)
DOI: 10.1177/096032719301200511
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