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Human & Experimental Toxicology
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*Compound via MeSH
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*12-O-TETRADECANOYLPHORBOL-13-ACETATE
*LACTIC ACID
*MERCURIC CHLORIDE
*MERCURY COMPOUNDS
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Methyl Mercury, Mercuric Chloride, and Silver Lactate Decrease Superoxide Anion Formation and Chemotaxis in Human Polymorphonuclear Leucocytes

Niels Obel

Department of Medicine and Infectious Diseases, Marselisborg Hospital, Aarhus, Denmark

Birte Hansen

Department of Medicine and Infectious Diseases, Marselisborg Hospital, Aarhus, Denmark

Margot M. Christensen

Department of Neurobiology, Institute of Anatomy, University of Aarhus, Denmark

Søren Lyhne Nielsen

Department of Medicine and Infectious Diseases, Marselisborg Hospital, Aarhus, Denmark

Jørgen Rungby

University Department of Endocrinology and Metabolism, Aarhus County Hospital, Aarhus, Denmark

Cytotoxic effects of mercuric chloride, methyl mercury, and silver lactate on polymorphonuclear leucocytes have been examined by assaying superoxide anion formation capability and chemotaxis of metal-exposed cells. Both superoxide anion formation and chemotaxis were negatively affected by all three metal compounds. Both bacteriotoxic functions were affected in a dose-dependent fashion, the functional deficits were seen at doses not affecting cell viability. Dose-response curves were remarkably similar for all three compounds. The bacteriotoxic capacity of polymorphonuclear leucocytes may be hampered by mercury and silver.

Human & Experimental Toxicology, Vol. 12, No. 5, 361-364 (1993)
DOI: 10.1177/096032719301200503
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