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interactive Potential of Omega-3 Fatty Acids with Clofibrate or DEHP on Hepatic Peroxisome Prolifieration in Male Wistar Rats

Environmental Health Sciences Program, School of Public Health, University of Massachusetts, Amherst, Massachusetts 01003, USA

Linda A. Baldwin

Environmental Health Sciences Program, School of Public Health, University of Massachusetts, Amherst, Massachusetts 01003, USA

Denise A. Leonard

Environmental Health Sciences Program, School of Public Health, University of Massachusetts, Amherst, Massachusetts 01003, USA

Edward J. Calabrese

Environmental Health Sciences Program, School of Public Health, University of Massachusetts, Amherst, Massachusetts 01003, USA

The interactive potential of three known peroxisome proliferators, omega-3 fatty acids, clofibrate and di(2-ethylhexylphthalate (DEHP), was evaluated in male weanling Wistar rats for the effect on peroxisomal beta-oxidation. Omega-3 fatty acids were supplied by menhaden oil which was fed in six regimens: low fat (5% w/w), low fat and clofibrate (0.3% w/w) or DEHP (0.25% w/w), high fat (20% w/w), high fat and clofibrate or DEHP in the aforementioned concentrations. Induction of peroxisomal beta-oxidation was measured by changes in liver-to-body weight ratio, fatty acyl-CoA oxidase (FAO) activity, and peroxisomal bifunctional enzyme (PBE) quantity. Analysis of transformed data indicated a less than additive response in FAO activity with no deviation from additivity seen with liver-to-body ratios and PBE.

Human & Experimental Toxicology, Vol. 12, No. 4, 337-340 (1993)
DOI: 10.1177/096032719301200413


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