This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Orisakwe, O.E. Articles by Obi, N. Search for Related Content PubMed PubMed Citation Articles by Orisakwe, O.E. Articles by Obi, N. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Hazardous Substances DB CHARCOAL DIAZINON Social Bookmarking                         What's this?

In Vitro and In Vivo Adsorption Stud ies of Diazinon

Toxicology Unit, Department of Pharmacology, College of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, Anambra State

N. Obi

Food and Drug Administration, Ministry of Health, Lagos, Nigeria

The in vitro and in vivo adsorption of diazinon to two brands of activated charcoal and locally produced carbon black (N220) has been studied. Solutions of diazinon 10, 20 and 40 µg ml^-1 were prepared in distilled water and different quantities of adsorbent added. Diazinon-adsorbent slurries were vortex mixed, centrifuged and analysed for free diazinon spectrophotometrically at 241 nm. Small quantities of activated charcoal (AC) and carbon black (CB) showed little or no adsorption of diazinon, while 1000 mg of either AC or CB was able to take up more than 70% at all concentrations of diazinon tested. In acute toxicity tests in mice the optimal adsorbent: diazinon ratio was 8:1 when the animals were treated with 45 mg kg^-1 diazinon after immediate, 1, and 3 h post administration of the adsorbent.

Human & Experimental Toxicology, Vol. 12, No. 4, 301-303 (1993)
DOI: 10.1177/096032719301200408


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?