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Chromosomal Aberrations Induced by Methyl Parathion in Human Peripheral Lymphocytes of Alcoholics and Smokers

Department of Biochemistry, University of Kerala, Karaivattom, Trivandrum

Raveendran Ankathil

Regional Cancer Centre, Trivandrum, India

K.S. Devi

Department of Biochemistry, University of Kerala, Karaivattom, Trivandrum

1 Two different concentrations (0.08 and 0.16 µg ml^-1) of methyl parathion (MP), a broad-spectrum insecticide, were tested on peripheral lymphocytes of healthy non-smoking non-alcoholics (CN), chronic smokers (SM) and alcoholics with smoking habit (ALSM).

2 SM and ALSM revealed a significant increase in chromosome aberration frequencies in peripheral lymphocytes compared to the CN group.

3 MP did not induce chromosomal aberrations in vitro in the CN group at either of the concentrations tested.

4 In SM and ALSM , MP induced a significant increase in chromosomal aberrations in vitro in peripheral lymphocytes at a concentration of 0.16 µg ml^-1.

5 The results indicate that the damage induced by MP in peripheral lymphocytes is potentiated by smoking and alcohol intake.

Human & Experimental Toxicology, Vol. 12, No. 4, 285-288 (1993)
DOI: 10.1177/096032719301200405


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