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Human & Experimental Toxicology
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Modulation of Biochemical and Cytological Profile of Bronchoalveolar Lavage Constituents in Rats Following Split-Dose Multiple Inhalation Exposure to Methyl Isocyanate

G.S.D. Gupta

Industrial Toxicology Research Centre, Post Box 80, M.G. Marg, Lucknow-226 001, India

R. Bajpai

Industrial Toxicology Research Centre, Post Box 80, M.G. Marg, Lucknow-226 001, India

J.L. Kaw

Industrial Toxicology Research Centre, Post Box 80, M.G. Marg, Lucknow-226 001, India

K.K. Dutta

Industrial Toxicology Research Centre, Post Box 80, M.G. Marg, Lucknow-226 001, India

P.K. Ray

Industrial Toxicology Research Centre, Post Box 80, M.G. Marg, Lucknow-226 001, India

1 Studies were carried out to explore the acute pulmonary effects of equal, split-dose, multiple inhalation exposures of rats to methyl isocyanate (MIC), (0.32 mg l -1, 8 min x 10 exposures) as reflected by alterations in bronchoalveolar lavage fluid (BALF) constituents and to evaluate recovery, if any, following survival in a MIC-free environment, 10 d after the last MIC exposure.

2 In the BALF of MIC-exposed rats, there was an increase in the total number of cells and the number of cells showing enhanced dye uptake and reduction of nitroblue tetrazolium chloride. The cell-free BALF showed increases in total protein, sialic acids and lactic acid contents and lactate dehydrogenase activity.

3 In rats exposed to MIC and sacrificed 10 d after survival in a MIC-free environment, there was a reduction in the cellular and biochemical constituents of BALF. The phagocytic potential of macrophages was, however, also decreased under this regime.

Human & Experimental Toxicology, Vol. 12, No. 3, 253-257 (1993)
DOI: 10.1177/096032719301200309
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