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Human & Experimental Toxicology
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Evaluation of a New Chelating Agent for Cadmium: A Preliminary Report

M. Gulumian

Department of Biochemistry, National Centre for Occupational Health, Department of National Health and Population Development, P O Box 4788, Johannesburg, 2000

E. Casimiro

Department of Biochemistry, National Centre for Occupational Health, Department of National Health and Population Development, P O Box 4788, Johannesburg, 2000

P.W. Linder

Department of Chemistry, University of Cape Town, Rondebosch 7700

D.B.K. Rama

Department of Biochemistry, National Centre for Occupational Health, Department of National Health and Population Development, P O Box 4788, Johannesburg, 2000

R.D. Hancock

Department of Chemistry, University of The Witwatersrand, P O Wits 2050, Johannesburg, Republic of South Africa

The Plasma Mobilizing Index parameters of the newly synthesized chelating agent THP-12-ane N4, determined by computer simulation studies, have indicated that this chelating agent might be a good antagonist for cadmium intoxication. Experiments conducted on rats confirmed this observation and showed that THP-12-ane N4 might have the ability to chelate and mobilize cadmium in vivo.

Human & Experimental Toxicology, Vol. 12, No. 3, 247-251 (1993)
DOI: 10.1177/096032719301200308
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