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Removal of Inhaled Plutonium and Americium from the Rat by Administration Of ZnDTPA in Drinking Water

National Radiological Protection Board, Chilton, Didcot, Oxon OX11 0RQ, UK

S.A. Gray

National Radiological Protection Board, Chilton, Didcot, Oxon OX11 0RQ, UK

M. Ellender

National Radiological Protection Board, Chilton, Didcot, Oxon OX11 0RQ, UK

M. Pearce

National Radiological Protection Board, Chilton, Didcot, Oxon OX11 0RQ, UK

I. Wilson

National Radiological Protection Board, Chilton, Didcot, Oxon OX11 0RQ, UK

J.C. Moody

National Radiological Protection Board, Chilton, Didcot, Oxon OX11 0RQ, UK

A. Hodgson

National Radiological Protection Board, Chilton, Didcot, Oxon OX11 0RQ, UK

This study has examined the efficacy of ZnDTPA administered in drinking water for removing 238Pu and ²⁴¹Am from the rat after their simultaneous inhalation as nitrates; the dosage used was 95 µmol kg^-1d^-1. The continuous administration of ZnDTPA over a 14 d interval, commencing 1 h after exposure, reduced the lung and total body contents of ²³⁸ Pu to, respectively, 11 % and 18% of those in untreated rats; the corresponding values for ²⁴¹Am were 11 % and 14%. After the continuous administration of 95 µmol kg^-1 from 4 d to 28 d post exposure, the lung and total body contents of ²³⁸Pu were, respectively, 5% and 16% of those in controls; the corresponding values for ²⁴¹Am were 7% and 19%. Further reductions in the actinide contents of body tissues were found when treatment was extended to 52 d or 76 d. These regimens were as effective as twice weekly injections of 30 µmol kg^-1 ZnDTPA commencing at 4 d. After the continuous administration of 95 µmol kg ^-1 d^-1 for 72 d, some pathological changes to the gastrointestinal tract were observed but these were considered to be reparable. It was concluded that further work is required to evaluate the toxicity of the ligand and to establish the optimal treatment regimen.

Human & Experimental Toxicology, Vol. 12, No. 3, 233-239 (1993)
DOI: 10.1177/096032719301200306


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