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Human & Experimental Toxicology
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*2-METHOXYETHANOL
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*Testicular Disorders
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An investigation of Urinary Creatine Excretion as a Potential Marker for Testicular Damage

Kamil Nahas

Laboratoires Pfizer, Centre de Recherche, Amboise Cedex, France

Jean-Loic le Net

Laboratoires Pfizer, Centre de Recherche, Amboise Cedex, France

Jean P. Provost

Laboratoires Pfizer, Centre de Recherche, Amboise Cedex, France

Konrad E. Tomaszewski

Pfizer Central Research, Sandwich, Kent CT13 9NJ, UK

1 This study assessed urinary creatine excretion as a marker for testicular atrophy.

2 Male rats received a single i.p. dose of 2-methoxyethanol at 0, 250 or 750 mg kg-1 and were sacrificed 2 d later. Urinary creatine and creatinine excretion were measured on days 0, 1 and 2.

3 Decreased testicular weights and histopathological assessment revealed dose-related testicular damage.

4 On day 1, at both doses of 2-methoxyethanol, urinary creatine levels increased and creatinine levels decreased, resulting in a dose-related increase in the creatine/creatinine ratio. On day 2, the creatine/creatinine ratio was elevated relative to controls, but was less marked than on day 1.

5 The study confirmed that creatine excretion is a potential marker for acute testicular damage.

Human & Experimental Toxicology, Vol. 12, No. 2, 173-176 (1993)
DOI: 10.1177/096032719301200214
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