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Human & Experimental Toxicology
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*Compound via MeSH
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Hazardous Substances DB
*1,1-DIMETHYLUREA
*LACTIC ACID
*METHYL ISOCYANATE
*UREA
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Do the Hydrolysis Products, Methylamine and N,N'-Dimethylurea, Play any Role in the Methyl Isocyanate-Induced Haematological and Biochemical Changes in Rabbits?

K. Jeevaratnam

Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Gwalior-474002, India

K. Sugendran

Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Gwalior-474002, India

C.S. Vaidyanathan

Department of Biochemistry, Indian Institute of Science, Bangalore-560012, India

The subcutaneous administration of methyl isocyanate (MIC) to female rabbits, resulted in significant increases in haemoglobin concentration, erythrocyte volume fraction and leucocyte number in blood, as well as plasma total proteins, and urea. The present study was designed to investigate whether the hydrolytic products of MIC, methylamine (MA) and N,N'-dimethylurea (DMU) play any role in eliciting these changes. Both MA and DMU administered subcutaneously in an equimolar dose to that of 1.0 LD50 MIC, 2.2 mmol kg-1, had no influence on these parameters, although there was a marginal increase in the plasma urea level shortly after the administration of DMU. This study establishes that the observed haematological and biochemical changes induced by MIC intoxication in rabbits are mostly due to MIC.

Human & Experimental Toxicology, Vol. 12, No. 2, 135-139 (1993)
DOI: 10.1177/096032719301200207
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