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Human & Experimental Toxicology
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Embryo-Fetal Development Influenced by Lead Exposure in Iron-Deficient Rats

C. Singh

Neurotoxicology Division, Industrial Toxicology Research Centre, P.O. Box No. 80, Mahatma Gandhi Marg, Lucknow 226001, India

D.K. Saxena

Neurotoxicology Division, Industrial Toxicology Research Centre, P.O. Box No. 80, Mahatma Gandhi Marg, Lucknow 226001, India

R.C. Murthy

Neurotoxicology Division, Industrial Toxicology Research Centre, P.O. Box No. 80, Mahatma Gandhi Marg, Lucknow 226001, India

S.V. Chandra

Neurotoxicology Division, Industrial Toxicology Research Centre, P.O. Box No. 80, Mahatma Gandhi Marg, Lucknow 226001, India

Lead administered (250, 500, 1000 and 2000 ppm Pb as lead nitrate) through drinking water from the 6th to the 14th day of gestation in iron-deficient rats, resulted in a significantly reduced litter size, reduced fetal weight and a reduced crown-rump length, increased resorption and a higher blood-lead uptake in those groups receiving 1000 and 2000 ppm Pb. These animals also had a higher placental lead uptake. However, the level was the same in both groups. Fetal lead uptake remained the same whether or not 2000 ppm lead was given to an iron-deficient or normal iron groups of mothers. This indicates that iron-deficiency renders female rats more susceptible to inducing embryo- and feto-toxicity when given lead through their drinking water.

Human & Experimental Toxicology, Vol. 12, No. 1, 25-28 (1993)
DOI: 10.1177/096032719301200105
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