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Human & Experimental Toxicology
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Mobilization and Distribution of Beryllium Over the Course of Chelation Therapy with Some Polyaminocarboxylic Acids in the Rat

Seema Mathur

School of Studies in Zoology, Jiwaji University

S.J.S. Flora

Division of Pharmacology and Toxicology, Defence Research & Development Establishment, Gwalior - 474 002, India

R. Mathur

School of Studies in Zoology, Jiwaji University

S. Das Gupta

Division of Pharmacology and Toxicology, Defence Research & Development Establishment, Gwalior - 474 002, India

The efficacy of three common polyaminocarboxylic acids in the treatment of experimental beryllium intoxication was investigated in male rats. N-(2-hydroxyethyl) ethylene diamine triacetic acid (HEDTA) was more effective than calcium disodium ethylenediamine tetraacetic acid (CaNa2EDTA) in reducing the beryllium concentration of the blood, kidneys and spleen and reducing beryllium-induced inhibition of hepatic alkaline phosphatase activity. HEDTA was also most effective in reducing histopathological lesions in the liver and spleen. Compared to these two chelators, the third amino chelator, calcium trisodium diethylene triaminepenta acetic acid (CaNa3DTPA) produced severe deleterious effects in the liver and systemic toxicity. The results suggest that HEDTA is a promising chelator for beryllium toxicity while DTPA enhances the toxic manifestation of beryllium.

Human & Experimental Toxicology, Vol. 12, No. 1, 19-24 (1993)
DOI: 10.1177/096032719301200104
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