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Human & Experimental Toxicology
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Hazardous Substances DB
*DIFENACOUM
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Difenacoum Poisoning as a cause of Haematuria

Graham P. Butchery

Ealing General Hospital, Uxbridge Road, Southall, Middlesex

Martin J. Shearer

Department of Haematology, Guys Hospital, London

Alan D. MacNicoll

Central Science Laboratory, MAFF, Tolworth, Surrey, UK

Michael J. Kelly

Central Science Laboratory, MAFF, Tolworth, Surrey, UK

Philip W. Ind

Ealing General Hospital, Uxbridge Road, Southall, Middlesex

A man presented with frank haematuria and a grossly prolonged prothrombin time. He was later found to have taken an overdose of difenacoum — a 'superwarfarin' rodenticide. The diagnosis was confirmed by a serum concentration of difenacoum of 0.6 µg ml-1. Overdosage with superwarfarins is discussed and the need for prolonged treatment with vitamin K1 highlighted.

Human & Experimental Toxicology, Vol. 11, No. 6, 553-554 (1992)
DOI: 10.1177/096032719201100620
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