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Chronic Exposure to n-Hexane Induces Changes in Nerve-Specific Marker Proteins in the Distal Peripheral Nerve of the Rat

Department of Hygiene, Nagoya University School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466

Eiji Shibata

Department of Hygiene, Nagoya University School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466

Kanefusa Kato

Department of Biochemistry, Institute for Developmental Research, Aichi Prefectural Colony, Kasugai, Aichi, Japan

Nobuyuki Asaeda

Department of Hygiene, Nagoya University School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466

Yasuhiro Takeuchi

Department of Hygiene, Nagoya University School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466

1 After long-term n-hexane exposure (2000 ppm, 12 h d^-1, 6 d week^-1, for 24 weeks), the content of neuron-specific enolase (gamma-enolase), creatine kinase-B and beta-S100 protein in the cortex, cerebellum, spinal cord and proximal and distal sciatic nerves of rats was determined by enzyme immunoassay.

2 The amounts of the three proteins decreased significantly in the distal segment of sciatic nerve, whereas they remained unchanged in the brain and proximal sciatic nerve. The quantitative decline in these marker proteins in the distal sciatic nerve could be related to neurophysiological deficits in the peripheral nerves.

3 This study indicates that the biochemical changes observed are consistent with the clinical and pathological findings of n-hexane neuropathy. These nerve-specific marker proteins can be used to assess solvent-related peripheral neurotoxicity.

Human & Experimental Toxicology, Vol. 11, No. 5, 323-327 (1992)
DOI: 10.1177/096032719201100504


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