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Differences in the Radiotoxicity of Two Plutonium Isotopes in Cells In Vitro: Can they be Ascribed to Different Handling by the Cells?

Kernforschungszentrum Karlsruhe, Institut fur Genetik und Toxikologie, Postfach 3640, D-7500 Karlsruhe 1, Germany

Waltraud Rau

Kernforschungszentrum Karlsruhe, Institut fur Genetik und Toxikologie, Postfach 3640, D-7500 Karlsruhe 1, Germany

Felicitas Planas-Bohne

Kernforschungszentrum Karlsruhe, Institut fur Genetik und Toxikologie, Postfach 3640, D-7500 Karlsruhe 1, Germany

Exposure of Co631 cells to plutonium leads to increasing cell death depending on the dose and incubation time. The effects, however, are more pronounced with ²³⁹Pu, than with ²³⁸Pu.

Uptake and binding of the two radionuclides during a 5-h incubation are about equal, but ²³⁸Pu is lost more rapidly from the cell. There are also differences in the subcellular distribution which lead to a pronounced difference in the distribution of radioactivity.

The influence of these differences in the handling of ²³⁸Pu and ²³⁹Pu by the cell and of the mass difference on the radiotoxicity of the radionuclides is discussed.

Human & Experimental Toxicology, Vol. 11, No. 3, 163-166 (1992)
DOI: 10.1177/096032719201100303


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