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Interindividual Variations in Enzymes Controlling Organophosphate Toxicity in Man

Toxicology Unit, Division of Environmental and Occupational Medicine, The Medical School, Newcastle University, Newcastle upon Tyne NE2 4HH, UK

Peter G. Blain

Toxicology Unit, Division of Environmental and Occupational Medicine, The Medical School, Newcastle University, Newcastle upon Tyne NE2 4HH, UK

Faith M. Williams

Toxicology Unit, Division of Environmental and Occupational Medicine, The Medical School, Newcastle University, Newcastle upon Tyne NE2 4HH, UK

1 Interindividual variations in an unexposed population have been defined for five enzymes involved in organophosphate (OP) toxicity. The enzymes measured were: red blood cell acetylcholinesterase (AChE), lymphocyte neuropathy target esterase (NTE), serum cholinesterase (ChE), serum paraoxonase and serum arylesterase.

2 AChE and arylesterase were normally distributed in the population whilst the distribution of NTE, ChE and paraoxonase deviated significantly from normal.

3 Assay precision and intra-individual variability were measured for each of the enzymes; the effect on interindividual variation was assessed.

4 Variations in enzyme activities between individuals could have profound effects on susceptibility to OP toxicity. Prior determination of these enzymes may be predictive of susceptibility.

5 Lymphocyte NTE has some limitations as an indicator of exposure to neurotoxic OPs.

Human & Experimental Toxicology, Vol. 11, No. 2, 109-116 (1992)
DOI: 10.1177/096032719201100209


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