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Drug Interaction between Rifampicin, Isoniazid and Cotrimoxazole in Rabbits

Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India

R. Uppal

Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India

P.L. Sharma

Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India

1 The results of cotrimoxazole (CTZ) co-administration (15 mg kg^-1 trimethoprim + 40 mg kg^-1 sulphamethoxazole) on plasma concentration and various pharmacokinetic parameters of rifampicin (RIF, 24 mg kg^-1) and isoniazid (INH, 14 mg kg^-1) were studied.

2 In the test group (n = 6), CTZ was administered on the 24th day of antitubercular treatment (ATT) and given for 7 d.

3 At the end of concurrent treatment with CTZ, RIF half-life (t) and plasma concentration were both increased. However, there was no effect on INH half-life and plasma concentration.

Human & Experimental Toxicology, Vol. 11, No. 2, 105-107 (1992)
DOI: 10.1177/096032719201100208


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