SAGE Journals Online
Advertisement
Sign In to gain access to subscriptions and/or personal tools.

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Advertisement

Sign In to gain access to subscriptions and/or personal tools.
Human & Experimental Toxicology
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Bray, G. P.
Right arrow Articles by Williams, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bray, G. P.
Right arrow Articles by Williams, R.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

The Effect of Chronic Alcohol Intake on Prognosis and Outcome in Paracetamol Overdose

Gary P. Bray

Institute of Liver Studies, King's College Hospital and King's College School of Medicine and Dentistry, Denmark Hill, London SE5 8RX, UK

Craig Mowat

Institute of Liver Studies, King's College Hospital and King's College School of Medicine and Dentistry, Denmark Hill, London SE5 8RX, UK

Douglas F. Muir

Institute of Liver Studies, King's College Hospital and King's College School of Medicine and Dentistry, Denmark Hill, London SE5 8RX, UK

J. Michael Tredger

Institute of Liver Studies, King's College Hospital and King's College School of Medicine and Dentistry, Denmark Hill, London SE5 8RX, UK

Roger Williams

Institute of Liver Studies, King's College Hospital and King's College School of Medicine and Dentistry, Denmark Hill, London SE5 8RX, UK

1 In a retrospective study, we stratified 79 patients with paracetamol hepatotoxicity into two groups according to weekly alcohol consumption below (n = 49) or above (n = 30) Royal College of Physicians' guidelines of 21 units week -1 for males and 14 for females.

2 Survival was lower (33%) and serum creatinine on admission higher (median 207 µmol) in patients whose alcohol consumption was above recommended guidelines than in those whose drank less than this (65.9% and 138 µmol, P < 0.01 and P = 0.027, respectively). An arterial blood pH < 7.30 on admission was also more common in those patients with a higher alcohol consumption (30% v 12.2%, P = 0.05).

3 In all patients whose alcohol consumption exceeded the guidelines, paracetamol overdose was fatal if associated with a serum creatinine greater than 300 µmol in conjunction with a prothrombin time over 100 s and grade 3 or 4 encephalopathy or a peak prothrombin time over 180 s.

4 Chronic alcohol intake above suggested limits is an adverse prognostic feature in cases of severe paracetamol overdose. This effect is partly related to increased nephrotoxicity.

Human & Experimental Toxicology, Vol. 10, No. 6, 435-438 (1991)
DOI: 10.1177/096032719101000612
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?




Advertisement