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Human & Experimental Toxicology
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Drug Interaction between Rifampicin and Cotrimoxazole in Patients with Tuberculosis

R.S. Bhatia

Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India

R. Uppal

Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India

R. Malhi

Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India

D. Behera

Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India

S.K. Jindal

Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India

1 Patients ( n = 15) who were admitted with complications of tuberculosis, were given antitubercular therapy (ATT) with rifampicin (RIF), for a minumum period of 15 d, and cotrimoxazole (CTZ), concurrently, for 5-10 d.

2 The serum RIF levels were measured before the start of CTZ treatment and at the end of its administration.

3 The plasma half-life (t1/2) of RIF increased significantly from 1.92 ± 0.57 h to 2.31 ± 0.134 h after CTZ treatment.

4 The mean serum levels of RIF increased significantly at 4 and 6 h after CTZ administration.

Human & Experimental Toxicology, Vol. 10, No. 6, 419-421 (1991)
DOI: 10.1177/096032719101000609
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This article has been cited by other articles:


Home page
 Arch Intern MedHome page
V. A. Strayhorn, A. M. Baciewicz, and T. H. Self
Update on Rifampin Drug Interactions, III
Arch Intern Med, November 24, 1997; 157(21): 2453 - 2458.
[Abstract] [PDF]


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