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Human & Experimental Toxicology
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Symptomatic Bradycardia Caused by Mianserin at Therapeutic Doses

Bernard Carcone

Service de Médecine, Interne et Cardiologie, Hôtel Dieu, 71206 Le Creusot

Thierry Vial

Post-Marketing Drug Surveillance and Poison Control Center, E. Herriot Hospital, 69003 Lyon, France

Nicolas Chaillet

Service de Médecine, Interne et Cardiologie, Hôtel Dieu, 71206 Le Creusot

Jacques Descotes

Post-Marketing Drug Surveillance and Poison Control Center, E. Herriot Hospital, 69003 Lyon, France

An acute episode of symptomatic sinus bradycardia, occurred in a 50-year-old female patient after she had been given a single therapeutic dose of mianserin. Heart rate was corrected by atropine injection. Re-administration of mianserin resulted in the recurrence of bradycardia. Further examination showed no cardiac abnormalities. This case is the first report of conduction defect in a patient given therapeutic doses of mianserin.

Human & Experimental Toxicology, Vol. 10, No. 5, 383-384 (1991)
DOI: 10.1177/096032719101000514
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