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Failure of a 21-Aminosteroid Antioxidant to Ameliorate Cisplatin-Induced Nephrotoxicity

Department of Pharmacology and Therapeutics, University of Liperpool, P.O. Box 147, Liverpool L69 3BX, UK

P.M. Stell

Department of Otorhino-laryngology, University of Liverpool, P.O. Box 147, Liverpool L69 3BX, UK

W.E. Lindup

Department of Pharmacology and Therapeutics, University of Liperpool, P.O. Box 147, Liverpool L69 3BX, UK

1 Lazaroid (U74500A), a 21-aminosteroid antioxidant, was administered to rats at a dose of 10 mg kg^-1 in an attempt to reduce the toxicity of cisplatin (5 mg kg ^-1).

2 No protective effect was apparent under the schedule used and, in contrast to other antioxidants and free-radical scavengers, U74500A offers no potential benefit in cisplatin treatment.

Human & Experimental Toxicology, Vol. 10, No. 5, 323-326 (1991)
DOI: 10.1177/096032719101000504


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