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Changes in Arterial Oxygen Tension after Gastric Lavage for Drug Overdose

Department of Internal Medicine and Intensive Care Medicine, Middelheim General Hospital, Lindedreef 1, B-2020 Antwerp, Belgium

Eric J. Joosens

Department of Internal Medicine and Intensive Care Medicine, Middelheim General Hospital, Lindedreef 1, B-2020 Antwerp, Belgium

Jan M. Nagler

Department of Internal Medicine and Intensive Care Medicine, Middelheim General Hospital, Lindedreef 1, B-2020 Antwerp, Belgium

1 Changes in arterial oxygen tension after gastric lavage were investigated in a prospective study of 55 patients admitted for drug overdose.

2 A significantly greater decrease was observed in smokers compared to non-smokers.

3 A correlation was found between the tricyclic antidepressant serum level and the observed oxygen tension decrease.

4 The usefulness, as well as the safety of the lavage procedure, in managing tricyclic antidepressants overdoses is controversial.

Human & Experimental Toxicology, Vol. 10, No. 3, 221-224 (1991)
DOI: 10.1177/096032719101000312


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