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The Formation of Methaemoglobin by 4-aminopropiophenone (PAPP) and 4-(N-hydroxy) aminopropiophenone

CDE Porton Down, Salisbury, Wilts SP4 0JQ

R.H. Inns

CDE Porton Down, Salisbury, Wilts SP4 0JQ

J.E. Bright

CDE Porton Down, Salisbury, Wilts SP4 0JQ

S.G. Wood

Huntingdon Research Centre PLC, Huntingdon, Cambs PE18 6ES, UK

Oral dosing of rats with the cyanide antidote 4-aminopropiophenone (PAPP), brought about peak methaemoglobin levels at 15-40 min, but peak levels were attained at 15-25 min after intravenous dosing. After both oral and intravenous administration at equimolar doses, 4-(N-hydroxy)aminopropiophenone (PHAPP), the putative methaemoglobin-producing metabolite of PAPP, produced higher peak levels of methaemoglobin than PAPP. Plasma from rats injected with PAPP was capable of forming methaemoglobin when added to naive rat erythrocytes. The identity of the metabolite responsible is discussed.

Human & Experimental Toxicology, Vol. 10, No. 3, 183-188 (1991)
DOI: 10.1177/096032719101000306


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