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Effects of a Cholecystokinin Receptor Antagonist on Rat Exocrine Pancreatic Response to Raw Soya Flour

Department of Toxicology, St Bartholomew's Hospital Medical College, Dominion House, 59 Bartholomew Close, London EC1 7ED, UK

A.D. Dayan

Department of Toxicology, St Bartholomew's Hospital Medical College, Dominion House, 59 Bartholomew Close, London EC1 7ED, UK

1 Raw soya flour (RSF) in the diet induces pancreatic hypertrophy and hyperplasia in the rat, changes ascribed to production of a high circulating level of cholecystokinin (CCK) due to inhibition of trypsin in the duodenum. Prolonged ingestion results in pancreatic adenomas and carcinomas.

2 L-364, 718, a potent, highly specific CCK antagonist was used to investigate the short-term role of CCK.

3 In rats fed 50% RSF and L-364, 718 5 mg kg^-1 p.o. twice daily for 4 d, there was inhibition of pancreatic hypertrophy and hyperplasia, which is further evidence that peripherally-acting CCK plays a major role in the generation of RSF-mediated changes in the pancreas.

Human & Experimental Toxicology, Vol. 10, No. 3, 179-182 (1991)
DOI: 10.1177/096032719101000305


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