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Absence of Polymorphism of Sparteine Oxidation in the South African Venda

Department of Pharmacology, University of Pretoria, Pretoria 0001, South Africa

J. Moncrieff

Department of Pharmacology, University of Pretoria, Pretoria 0001, South Africa

J.C. Avenant

Department of Pharmacology, University of Pretoria, Pretoria 0001, South Africa

1 This study has found no occurrence of poor metabolism of sparteine within a South African Venda populaton of 97 subjects.

2 On the basis of MR (metabolic ratio) the mean and distribution of the results are very similar to those found in Ghanaians.^5,14

3 The distribution is also similar to that for fast metabolizers in Caucasians.¹⁴

4 It is concluded that different P450 cytochromes are responsible for immediate oxidation of debrisoquine and sparteine, but that both may be activated by the same P450 reductase.

Human & Experimental Toxicology, Vol. 10, No. 3, 175-178 (1991)
DOI: 10.1177/096032719101000304


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