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Neurotoxicity of 1-Methoxycycloheptatriene - A Purkinje Cell ToxicantChemical Defence Establishment, Porton Down, Salisbury, Wiltshire SP4 0JQ, UK
Neuropathology, Institute of Pathology, Queen's University, Grosvenor Road, Belfast BT12 6BL, Northern Ireland, UK
Chemical Defence Establishment, Porton Down, Salisbury, Wiltshire SP4 0JQ, UK
Neuropathology, Institute of Pathology, Queen's University, Grosvenor Road, Belfast BT12 6BL, Northern Ireland, UK The toxicity of 1-methoxycycloheptatriene (1-MCHT), a sensory irritant, has been investigated in beagles. It was found to produce gross inco-ordination of the limbs at intravenous doses greater than 10 mg kg-1. The main histological abnormalities were in the cerebellum and consisted of Purkinje cell death and subsequent reactive gliosis. A few necrotic neurons were seen in the diencephalon, pons and medulla. Haematological abnormalities, e.g. leucocytosis with relative lymphopenia, were seen, while biochemical changes included hyperglycaemia and a rise in plasma aminotransferases. The no-effect dose for the histological and biochemical changes was the same. These abnormalities are compared with cerebellar changes observed in acrylamide and other toxic states.
Human & Experimental Toxicology, Vol. 10, No. 2,
93-101 (1991) |
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