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Human & Experimental Toxicology
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HI-6 in Man: Efficacy of the Oxime in Poisoning by Organophosphorus Insecticides

R. Kusic

Military Medical Academy, Clinic of Toxicology and Clinical Pharmacology, Crnotravska 17, 11 000 Belgrade

D. Jovanovic

Military Technical Institute, Medical Department, Kataniceva 15, 11.000 Belgrade, Yugoslavia

S. Randjelovic

Military Medical Academy, Clinic of Toxicology and Clinical Pharmacology, Crnotravska 17, 11 000 Belgrade

D. Joksovic

Military Medical Academy, Clinic of Toxicology and Clinical Pharmacology, Crnotravska 17, 11 000 Belgrade

V. Todorovic

Military Medical Academy, Clinic of Toxicology and Clinical Pharmacology, Crnotravska 17, 11 000 Belgrade

B. Boskovic

Military Technical Institute, Medical Department, Kataniceva 15, 11.000 Belgrade, Yugoslavia

M. Jokanovic

Military Technical Institute, Medical Department, Kataniceva 15, 11.000 Belgrade, Yugoslavia

V. Vojvodic

Military Medical Academy, Clinic of Toxicology and Clinical Pharmacology, Crnotravska 17, 11 000 Belgrade

The efficacy of the oxime HI-6 was studied as a treatment for organophosphorus poisoning. HI-6 was given four times daily as a single intramuscular injection of 500 mg accompanied by atropine and diazepam therapy. Oxime treatment was started on admission and continued for a minimum of 48 h and a maximum of 7 d. HI-6 rapidly reactivated human blood acetylcholinesterase inhibited by diethoxy organophosphorus compounds, while the dimethoxy-inhibited enzyme was mainly resistant to the treatment by HI-6. Although both HI-6 and pralidoxime chloride reactivated the red blood cell cholinesterase in quinalphos-poisoned subjects, the return of enzyme activities was more rapid following the use of HI-6. The general improvement of poisoned patients, which was sometimes more rapid than the rise of acetylcholinesterase activity, pointed to direct pharmacological effects of HI-6. No undesirable side-effects were noted in patients when HI-6 plasma concentrations were maintained at levels far above the 'therapeutic' concentration for up to 7 d.

Human & Experimental Toxicology, Vol. 10, No. 2, 113-118 (1991)
DOI: 10.1177/096032719101000204
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