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Dopamine and Dobutamine Reduce Myocardial d-Propoxyphene Content in Experimentally Intoxicated Rats

Department of Anaesthesia and Intensive Care, the Municipal Hospital of Copenhagen, DK-1399 Copenhagen, Denmark

J. Str�m

Department of Anaesthesia and Intensive Care, the Municipal Hospital of Copenhagen, DK-1399 Copenhagen, Denmark

H.R. Angelo

Department of Anaesthesia and Intensive Care, the Municipal Hospital of Copenhagen, DK-1399 Copenhagen, Denmark

A. Munksgaard

Department of Anaesthesia and Intensive Care, the Municipal Hospital of Copenhagen, DK-1399 Copenhagen, Denmark

S. H�gskilde

Department of Anaesthesia and Intensive Care, the Municipal Hospital of Copenhagen, DK-1399 Copenhagen, Denmark

M. Bredgaard S�rensen

Department of Anaesthesia and Intensive Care, the Municipal Hospital of Copenhagen, DK-1399 Copenhagen, Denmark

The effect of sympathomimetic intervention with dopamine or dobutamine on the myocardial uptake of d-propoxyphene was investigated experimentally in rats.

The d-propoxyphene (19 mg kg^-1 h^-1) was continously infused, intravenously, over 45 min. After 20 min of infusion the rats were given either dopamine (12.5 ?g kg^-1 min^-1 or 25 ?g kg^-1 min^-1), dobutamine (25 ?g kg^-1 min^-1 or 45 ?g kg^-1min^-1) or normal saline (control). Each group consisted of eight rats.

The myocardial d-propoxyphene content was significantly lower in the two groups given dopamine and in the group given dobutamine 45 ?g kg^-1 min^-1 than in the control group (P < 0.05).

This finding indicates the benefit of early sympathomimetic intervention with either dopamine or dobutamine in d-propoxyphene intoxication.

Human & Experimental Toxicology, Vol. 10, No. 2, 109-112 (1991)
DOI: 10.1177/096032719101000203


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