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Human & Experimental Toxicology
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*Compound via MeSH
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*CALCIUM COMPOUNDS
*CALCIUM, ELEMENTAL
*SARIN
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A Histochemical Study of Changes Observed in the Mouse Diaphragm after Organophosphate Poisoning

J.E. Bright

CDE Porton Down, Salisbury, Wilts SP4 0JQ, UK

R.H. Inns

CDE Porton Down, Salisbury, Wilts SP4 0JQ, UK

N.J. Tuckwell

CDE Porton Down, Salisbury, Wilts SP4 0JQ, UK

G.D. Griffiths

CDE Porton Down, Salisbury, Wilts SP4 0JQ, UK

T.C. Marrs

Present address: Department of Health, Hannibal House, Elephant and Castle, London SE1 6TE, UK

A sublethal dose of sarin (GB, isopropyl methylphosphonofluoridate) was administered to mice. The animals were killed up to 28 d after dosing and frozen sections were made of the excised diaghragms which were stained using haematoxylin and eosin and a modified Gomori trichrome method. Muscle fibre degeneration and mononuclear infiltration were seen, notably at 24 h and 3 d. A number of histochemical procedures were carried out, including the GBHA procedure for ionized calcium. Calcium accumulation, seen at 4 h, was the earliest abnormality observed. All changes were rapidly regressing by 5 d and histological appearances were normal by 14 d. It was concluded that sarin produced myopathic changes preceded by calcium accumulation.

Human & Experimental Toxicology, Vol. 10, No. 1, 9-14 (1991)
DOI: 10.1177/096032719101000102
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