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Human & Experimental Toxicology
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Life-Threatening Ventricular Arrhythmia (Torsades de Pointes) after Haloperidol Overdose

R.A. Henderson

Guy's Hospital, St. Thomas Street, London SE1 9RT, UK

S. Lane

Guy's Hospital, St. Thomas Street, London SE1 9RT, UK

J.A. Henry

Guy's Hospital, St. Thomas Street, London SE1 9RT, UK

A 48-year-old woman developed QT prolongation and episodes of life-threatening ventricular tachycardia (torsades de pointes) after intentional overdose of haloperidol and orphenadrine. The arrhythmia did not respond to conventional anti-arrhythmic therapy but was suppressed by atrial overdrive pacing. A literature review identified haloperidol as the most likely cause of the torsades de pointes.

Human & Experimental Toxicology, Vol. 10, No. 1, 59-62 (1991)
DOI: 10.1177/096032719101000110
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