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Human & Experimental Toxicology
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Studies on the Mutagenicity of a Zinc Oxide-Hexachloroethane Smoke

S.A. Clode

The British Industrial Biological Research Association, Woodmansterne Road, Carshalton, Surrey SM5 4DS, UK

R.A. Riley

The British Industrial Biological Research Association, Woodmansterne Road, Carshalton, Surrey SM5 4DS, UK

S.D. Blowers

The British Industrial Biological Research Association, Woodmansterne Road, Carshalton, Surrey SM5 4DS, UK

T.C. Marrs

Chemical Defence Establishment, Porton Down, Salisbury, Wiltshire SP4 OSQ, UK

D. Anderson

The British Industrial Biological Research Association, Woodmansterne Road, Carshalton, Surrey SM5 4DS, UK

1 A suitable method has been developed for generating atmospheres of zinc oxide/ hexachloroethane smoke (ZnHCE).

2 The smoke was investigated using the Ames test and the micronucleus assay.

3 It was weakly mutagenic to the bacteria, but in the bone marrow no increases in micronuclei were detected up to toxic levels of the smoke.

4 The method used here could be applied to other pyrotechnic mixtures which give rise to complex mixtures of products.

Human & Experimental Toxicology, Vol. 10, No. 1, 49-57 (1991)
DOI: 10.1177/096032719101000109
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This article has been cited by other articles:


Home page
 Hum Exp ToxicolHome page
D. Andersonl, S. Blowers, T. Marrs, and P. Rice
An in vitro and an in vivo unscheduled DNA synthesis assay with a zinc oxide/ hexachloroethane (Zn/HCE) smoke
Human and Experimental Toxicology, January 1, 1996; 15(1): 38 - 44.
[Abstract] [PDF]


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