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Human & Experimental Toxicology
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Expression of N-Acetyl Transferase in a Human Monocytic Cell-Line, U937

S.L. Kelly

Department of Pharmacology, University of Oxford, South Parks Road, Oxford OX1 3QT, UK

E. Sim

Department of Pharmacology, University of Oxford, South Parks Road, Oxford OX1 3QT, UK

1 N-acetyl transferase (NAT) catalyses the acetylation of arylamine and hydrazine drugs and other xenobiotics. The activity of one isozyme (polymorphic NAT) varies amongst indiviudals but the other (monomorphic NAT) does not.

2 The human monocytic cell-line U937 transcribes the gene for monomorphic N-acetyl transferase.

3 Although the gene for polymorphic N-acetyl transferase is present in these cells, its expression is not detected.

4 It is concluded that U937 cells are a useful model for studying the metabolism of arylamines and hydrazines by human monomorphic N-acetyl transferase.

Human & Experimental Toxicology, Vol. 10, No. 1, 33-38 (1991)
DOI: 10.1177/096032719101000106
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This article has been cited by other articles:


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V. A. Smelt, A. Upton, J. Adjaye, M. A. Payton, S. Boukouvala, N. Johnson, H. J. Mardon, and E. Sim
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[Abstract] [Full Text] [PDF]


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