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Increased Drug Effect Induced by Surgery

Department of Pharmacology and Therapeutics, University of Dundee, Scotland

1 A thyrotoxic patient receiving a constant dose of propranolol and digoxin developed marked bradycardia postoperatively.

2 Compared to preoperative levels there was a considerable rise postoperatively in both plasma propranolol and serum digoxin steady-state concentrations.

3 Surgery by effecting drug disposition and disease processes may significantly alter drug handling in the perioperative period.

Human & Experimental Toxicology, Vol. 1, No. 4, 447-449 (1982)
DOI: 10.1177/096032718200100412


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