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The Pulmonary Macrophages of Human Smokers: Decreased Surface Fc Receptor Concentrations on Heavily Particle-laden Cells

Cambridge University and MRC Department of Clinical Oncology and Radiotherapeutics

1 Human pulmonary macrophages (PM) have been obtained by broncho-pulmonary lavage from smokers and non-smokers. Smokers' PM tend to be larger cells with more particulate intracytoplasmic inclusions than non-smokers' cells.

2 Electronmicrographs show that the majority of inclusions are electron dense and within lysosomes. Other lysosomal inclusions in smokers' PM are needle-like structures and lamellar bodies.

3 A rosette assay that detects changes in surface F_c receptor expression was used to compare the F_c receptor expression of a PM subgroup that was heavily particle laden with a 'clean' PM subgroup.

4 There is strong evidence for reduced surface F_c receptor expression in heavily particle laden PM. The possible explanations of this difference are discussed.

Human & Experimental Toxicology, Vol. 1, No. 4, 433-442 (1982)
DOI: 10.1177/096032718200100410


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