This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Sangster, B. Articles by van Logten, M.J. Search for Related Content PubMed Articles by Sangster, B. Articles by van Logten, M.J. Social Bookmarking                         What's this?

Study of Sodium Bromide in Human Volunteers, with Special Emphasis on the Endocrine System

National Poison Control Centre, National Institute of Public Health, P.O. Box 1, Bilthoven, The Netherlands

E.I. Krajnc

Laboratory for General Toxicology, National Institute of Public Health, P.O. Box 1, Bilthoven, The Netherlands

J.G. Loeber

Laboratory for Endocrinology, National Institute of Public Health, P.O. Box 1, Bilthoven, The Netherlands

A.G. Rauws

Unit on Pharmacokinetics, National Institute of Public Health, P.O. Box 1, Bilthoven, The Netherlands

M.J. van Logten

Laboratory for General Toxicology, National Institute of Public Health, P.O. Box 1, Bilthoven, The Netherlands

1 Bromide, 1 mg kg^-1 daily, was administered to 21 healthy volunteers (11 females not using oral contraceptives and not pregnant and 10 males, during 8 weeks or 2 full cycles to determine whether ingestion of a dose equal to the acceptable daily intake might induce effects. Special attention was paid to the endocrine system because endocrine changes were predominant in rats receiving sodium bromide (NaBr) in their diets.

2 There was no difference between the results of a full medical history and physical examination at the start and at the end of the experiment.

3 The results from the measured haematological, biochemical and urine analyses did not change during the experiment.

4 In females the plasma bromide concentration rose from 0.08 ± 0.01 mmol 1^-1 to 0.97 ± 0.18 mmol 1^-1 and in males from 0.08 ± 0.01 mmol 1 ^-1 to 0.83 ± 0.09 mmol ^-1 (mean ± s.d.).

5 No changes were observed in the serum concentrations of thyroxine, free thyroxine, thyroxin binding globulin, triiodothyronine, cortisol, testosterone, estradiol and progesterone. Also no changes were observed in the serum concentrations of thyroid stimulating hormone (TSH), prolactin, luteinizing hormone (LH) and follicle stimulating hormone (FSH) before and after the administration of thyroid stimulating hormone releasing hormone (TRH) and luteinizing hormone releasing hormone (LHRH).

Human & Experimental Toxicology, Vol. 1, No. 4, 393-402 (1982)
DOI: 10.1177/096032718200100405


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?