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Genotoxic Activity of the Aminophenols as Evidenced by the Induction of Sister Chromatid Exchanges

Institut für Humangenetik, Medizinische Hochschule Lübeck, Ratzeburger Allee 160, D-2400 Lübeck, FRG

U. Bayer

Institut für Toxikologie, Medizinische Hochschule Lübeck, Ratzeburger Allee 160, D-2400 Lübeck, FRG

1 Most hair dyes contain the structural isomers ortho-, meta- and para-aminophenol which were investigated concerning their ability to induce sister chromatid exchanges (SCE) in cultured human lymphocytes in vitro and in Chinese hamster bone marrow cells in vivo.

2 In vitro only ortho-aminophenol significantly induced SCE in a dose-dependent manner.

3 In vivo none of the structural isomers increased significantly the SCE frequency.

4 It is concluded that ortho-aminophenol is a weak directly acting compound which is detoxified during its metabolism.

Human & Experimental Toxicology, Vol. 1, No. 4, 387-392 (1982)
DOI: 10.1177/096032718200100404


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