This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Heath, A. Articles by Ahlmén, J. Search for Related Content PubMed Articles by Heath, A. Articles by Ahlmén, J. Social Bookmarking                         What's this?

Treatment of Podophyllin Poisoning with Resin Hemoperfusion

Sahlgren's Hospital, University of Gothenburg, 413 45 Göteborg, Sweden

Tore Mellstrand

Sahlgren's Hospital, University of Gothenburg, 413 45 Göteborg, Sweden

Jarl Ahlmén

Sahlgren's Hospital, University of Gothenburg, 413 45 Göteborg, Sweden

1 A 43-year-old man was admitted in a coma after oral ingestion of a suspected lethal dose of podophyllin solution in alcohol.

2 Hemoperfusion with a resin filter was started 7 h after ingestion. Hemoperfusion rapidly decreased plasma concentrations of podophyllotoxin with an extraction ratio of 0.76 over the filter. The relatively low plasma concentrations of podophyllotoxin and consequently small amount removed might be explained by the rapid metabolism of the drug to an unknown derivate.

3 This metabolite was completely cleared during passage over the filter, suggesting the removal of significant amounts of podophyllotoxin metabolites.

4 No neurological deficit was observed before or after hemoperfusion. At a two-month follow-up the patient remained healthy. Hemoperfusion may possibly prevent the development of coma and neurologic deficit with loss of deep tendon reflexes.

Human & Experimental Toxicology, Vol. 1, No. 4, 373-378 (1982)
DOI: 10.1177/096032718200100402


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?