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Comparison of the Inhibitory Action of Delta-9-tetrahydrocannabinol and Petroleum Spirit Extract of Herbal Cannabis on Human Sperm Motility

Department of Clinical Pharmacology, St Bartholomew's Hospital, London EC 1A 7BE

D.M. Chaput de Saintonge

Department of Clinical Pharmacology, St Bartholomew's Hospital, London EC 1A 7BE

P. Turner

Department of Clinical Pharmacology, St Bartholomew's Hospital, London EC 1A 7BE

J.W. Fairbairn

Department of Pharmacognosy, The School of Pharmacy, University of London, London WC1N1AX

1 Using the trans-membrane migration method to measure drug effects on human sperm motility, it is found that -9-tetrahydrocannabinol is the major constituent of cannabis which inhibits sperm motility and unlike the cataleptic effect, other constituents in the petroleum spirit extract do not potentiate this effect significantly.

2 It is suggested that the mechanisms for sperm immobilization and cataleptic effects are different.

Human & Experimental Toxicology, Vol. 1, No. 2, 151-154 (1982)
DOI: 10.1177/096032718200100207


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