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Non-occupational Exposure to Pentachlorophenol: Clinical Findings and Plasma-PCP-concentrations in Three Families

National Poison Control Centre, National Institute of Public Health, PO Box 1, Bilthoven and Department of Reanimation and Clinical Toxicology, University Hospital, Utrecht, Catharijnesingel 101, Utrecht

R.C.C. Wegman

Unit for Residue Analysis, National Institute of Public Health, PO Box 1, Bilthoven, The Netherlands

A.W.M. Hofstee

Unit for Residue Analysis, National Institute of Public Health, PO Box 1, Bilthoven, The Netherlands

1 The clinical findings are reported of 15 members of three families living in houses where relatively large amounts of pentachlorophenol (PCP) solutions had been applied. To be able to interprete the plasma concentrations in the patients, plasma-PCP-concentrations in 99 draftees were measured. The clinical and toxicological-analytical results are discussed.

2 Signs of a systemic PCP-intoxication were not found in any patient.

3 Symptoms and objective changes of the uncovered skin were present in three patients (a burning painful sensation, erythema, dryness and scaling) possibly caused by a direct influence of PCP in the air.

4 The plasma-PCP-concentrations in the patients ranged from 25-660 µgl^-1. The mean plasma-PCP-concentrations in the draftees was 128.6±134.9µgl ^-1 (mean±s.d.); the median was 88 µg1^-1, the 95% range was 330 µg1^-1.

5 There was an association between patients' plasma-PCP-concentrations and their staying in the affected house.

Human & Experimental Toxicology, Vol. 1, No. 2, 123-133 (1982)
DOI: 10.1177/096032718200100204


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